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DRUGS

Alcohol
Nicotine
Drugs of Abuse
Drugs in Sport

 
SPECIMENS

Blood
Oral Fluid
Saliva
Urine
Sweat
Hair
DETECTION

Marijuana
Opiates
Amphetamine
Methamphetamine
Benzodiazepines
Cocaine
TESTING

Screening
Confirmation
On-site
Laboratory
COMPARISON

Urine vs.
Oral Fluid
GLOSSARY
STUDIES

 

 Studies

MANDATORY GUIDELINES for Federal Workplace Drug Testing Programs

 

MULTIPLE ANALYTES:

A Correlation Between the Levels of Phenobarbital, Phenytoin and Valproic Acid in the Blood Serum and in Saliva from Children Treated Due to Epilepsy

Reference: Sobaniec W.: Materia Medica Polona, 1989, Volume 21:323-326.

Adulterants Causing False Negatives in Illicit Drug Testing

Reference: Mikkelsen SL, Ash KO: Clinical Chemistry, 1988, Volume 34, Number 11, 2333-2336.

Aminotransferases and Lactate Dehydrogenase in Saliva of Diabetic Patients

Reference: Musumeci V, Cherubini P, Zuppi C, Zappacosta B, Ghirlanda G, DiSalvo S, Journal of Oral Pathol Medicine, 1993, Volume 22, Number 2:73-76.

Analysis of Drugs of Abuse in Saliva

Reference: Samyn N., Verstraete A., van Haeren C., Kintz P., Forensic Science Review, June 1999, Volume 11, Number 1, 1-19.

Analysis of Drugs in Unconventional Samples

Reference: Inoue T., Seta S: Forensic Sci Rev, December 1992, Volume 4, Number 2:89-106.

A Review of the Use of Saliva in the Forensic Detection of Drugs and Other Chemicals

Reference: Idowu O.R., Caddy B.: Journal of Forensic Science Society, 1982, Volume 22:123-135.

A Sensitive and Simple Assay of Saliva on Stamps

Reference: DeLeo D., Tagliaro F., Maschio S., Marigo M., Z Rechtsmed, 1985, Volume 95, 27-33.

A Survey of Pre-Placement Urinalysis Drug Findings

Reference: Wick RL, Brawley WL, Berger BT: Aviation, Space and Environmental Medicine, January 1992, 56-59.

An Untrafiltrate of Saliva Collected in Situ as a Biological Sample for Diagnostic Evaluation

Reference: Schramm W, Smith RH: Clinical Chemistry, 1991, Volume 37, Number 1:114-115.

Basic Biological Sciences - Secretion of Drugs by the Parotid Glands of Rats and Human Beings

Reference: DiGregorio G.J., Piraino A.J., Nagle B.T., Knaiz E.K., Journal Dental Res., May 1977, Volume 56, Number 5, 502-508.

Buffer Effect of Saliva In Vitro

Reference: Luoma H: Journal of Dental Registry, 4-8/66, Volume 45, Number 4:1231.

Buprenorphine Pharmacokinetics: Relative Bioavailability of Sublingual Tablet and Liquid Formulations

Reference: Nath RP, Upton RA, Everhart, ET, Cheung P, Shwonek P, Jones RT, Mendelson JE: Journal Clinical Pharmacol, 1999; Volume 39, 619-623.

Chemical Dependency and Drug Testing in the Workplace

Reference: Osterloh JD, Becker CE: Journal of Psychoactive Drugs, October-December 1990,Volume 22, Number 4:407-417.

Cocaine and Benzoylecgonine in Saliva, Serum and Urine

Reference: Schramm W, Craig PA, Smith RH, Berger GE: Clinical Chemistry, 1993, Volume 36, Number 3:481-487.

Comparison of Saliva and Urine Samples in Thin-Layer Chromatographic Detection of Central Nervous Stimulants

Reference: Vapaatalo H, Karkkainen S, Senius KEO, Int. J. Clinical Pharmacology Res, Volume IV, Number 1, (1984), 5-8.

Concentration of Cholesterol in Blood Serum and in Saliva

Reference: Manrique T., Odontologia, 1967, Volume 15, Number 1, 273. (Spanish)

Critical Issues in Urinalysis of Abused Substances: Report of the Substance-Abuse Testing Committee

Reference: Kwong TC, et al: Clinical Chemistry, 1988, Volume 34, Number 3, 605-632.

Cross-Reactivity of Stimulants Found in Sports Drug Testing by Two Fluorescence Polarization Immunoassays

Reference: de la Torre R, Badia R, Gonzalez G, Garcia M, Pretel MJ, Farre M, Segura J: Journal of Analytical Toxicology, May/June 1996, Volume 20, 165-170.

Current Diagnostic Uses of Saliva

Reference: Ferguson D.B., J. Dental Res., 1987, Volume 66, Number 2, 420-424.

Daily Salivary Anticonvulsant Monitoring in Patients with Intractable Epilepsy

Reference: Herkes, G.K., Eadie M.J., Clin Exp Neurol., 1989, Volume 26, 141-149.

Detection of Dexamethasone in Saliva

Reference: Thijssen JHH, Gispen-de Wied CC, van Heeswijk GM, Veeman W, Clinical Chemistry, 1996, Volume 42, Number 8, 1238-1242.

Detection of Drugs of Abuse by Radioimmunoassay: A Summary of Published Data and Some New Information

Reference: Cleeland R, Christenson J, Usategui-Gomez M, Heveran J, Davis R, Grunberg E: Clinical Chemistry, 1976, Volume 22, Number 6:712-725.

Detection of Drugs in Saliva of Impaired Drivers

Reference: Peel H.W., Perrigo B.J., Mikhael N.Z.: Journal of Forensic Sciences, 1984, Volume 29:185-189.

Driving Tests with Patients

Reference: deGier JJ: Br. J. Clin. Pharmac., 1984, Volume 18, 103S-108S.

Drug Analysis Technology - Pitfalls and Problems of Drug Testing

Reference: McBay AJ: Clinical Chemistry, 1987, Volume 33, Number 11(B) 33B-40B.

Drug Concentration in Saliva

Reference: Mucklow J.C., Bending M.R., Kahn G.C., Dollery C.T.: Clin. Pharmacol. Ther., November 1978, Volume 24, 563-570.

Drug Screening Practices in Small Businesses: A Survey

Reference: Godefroi R, McCunney RJ, Occupational Medicine Forum, 300, 302.

Drugs of Abuse in Saliva: A Review

Reference: Schramm W., Smith R.H., Craig P.A.: Journal of Analytical Toxicology, January/February 1992, Volume 16, 1-9.

Drug-Testing Methods and Reliability

Reference: Fretthold DW: Journal of Psychoactive Drugs, October-December 1990, Volume 22, Number 4, 419-428.

Elevated Drug Saliva Levels Suggest a "Depot-Like" Effect in Subjects Treated with Sublingual Buprenorphine

Reference: Cone EJ, Dickerson SL, Darwin WD, Fudala P, Johnson RE: National Institute on Drug Abuse, Research Monograph, 1991, Volume 105:569.

Evaluation of the Ames Seralyzer for the Determination of Carbamazepine, Phenobarbital, and Phenytoin Concentrations in Saliva

Reference: Miles M.V., Tennison M.B., Greenwood R.S., Benoit S.E., Thorn M.D., Messenheimer J.A., Ehle A.L.: Therapeutic Drug Monitoring, 1990, Volume 12, 501-510.

Excretion of Drugs in Saliva, Salicylate, Barbiturate, Sulfanilamide

Reference: Borzelleca J.F., Doyle C.H.: Journal of Oral Therapeutics and Pharmacology, September 1966, Volume 3, Number 2, 104-111.

False-Positive Postmortem EMIT Drugs of Abuse Assay Due to Lactate Dehydrogenase and Lactate in Urine

Reference: Sloop G, Hall M, Simmons GT, Robinson CA: Journal of Analytical Toxicology, November/December 1995, Volume 19, 554-556.

Human Saliva: Clinical Chemistry and Microbiology - Volume I

Reference: Jorma O. Tenovuo, D.Odont., CRC Press, Inc., Volume 1, 46-60.

Impact of Adulterants on RIA Analysis of Urine for Drugs of Abuse

Reference: Cody J.T., Schwarzhoff R.H., Journal of Analytical Toxicology, September/October 1989, Volume 13, 277-284.

Interactions Between Drugs and Saliva-Stimulating Parafilm and Their Implications in Measurements of Saliva Drug Levels

Reference: Chang K, Chiou WL: Research Communications in Chemical Pathology and Pharmacology, February 1976, Volume 13, Number 2:357-360.

Interactions Between Phencyclidine and D 9-Tetrahydrocannabinol in Mice Following Smoke Exposure

Reference: Freeman AS, Martin BR: Life Science, 1983,Volume 32, Number 10, 1081-1089.

Interference by Nonsteroidal Anti-Inflammatory Drugs in EMIT® and TDx® Assays for Drugs of Abuse

Reference: Joseph R, Dickerson S, Willis R, Frankenfield D, Cone EJ: Journal of Analytical Toxicology, January/February 1995, Volume 19, 13-17.

Interference of Common Household Chemicals in Immunoassay Methods for Drugs of Abuse

Reference: Warner A: Clinical Chemistry, 1989, Volume 35, Number 4:648-651.

Interference of Herbal Drinks with Urinalysis for Drugs of Abuse

Reference: Winek CL, Elzein EO, Wahba WW, Feldman JA, Journal of Analytical Toxicology, July/August 1993, Volume 17, 246-247.

Intraindividual Variability of Carbamazepine, Phenobarbital and Phenytoin Concentrations in Saliva

Reference: Miles MV, Tennison MB, Greenwood RS: Therapeutic Drug Monitoring, 1991, Volume 13, Number 2:166-171.

Investigation of Interference by Nonsteroidal Anti-Inflammatory Drugs in Urine Tests for Abused Drugs

Reference: Rollins DE, Jennison TA, Jones G: Clinical Chemistry, 1990, Volume 36, Number 4, 602-606.

Issues Associated with Testing for Drugs in Oral Fluids

Reference: Hamilton W, Drummer OH, Bulletin of the International Association of Forensic Toxicologists, 8-9.

Measurement of Drugs in Saliva: A Review

Reference: Paxton J.W.: Methods and Findings Exptl Clin. Pharmacol., 1979, Volume 1:11-21.

Monitoring Saliva Concentrations of Methaqualone, Codeine, Secobarbital, Diphenhydramine and Diazepam after Single Oral Doses

Reference: Sharp M.E., Wallace S.M., Hindmarsh K.W., Peel H.W.: Journal of Analytical Toxicology, January/February 1983, Volume 7, 11-14.

Nonsteroidal Anti-Inflammatory Drug Interference in TDx® Assays for Abused Drugs

Reference: Larsen J, Fogerson R: Clinical Chemistry, 1988, Volume 34, Number 5:987-988.

One Sample Antipyrine Clearance After 90% Partial Hepatectomy in the Rat

Reference: Poulsen HE, Liver 1985, Volume 5, 200-204.

Perspiration Versus Saliva - Basic Aspects Concerning Their Use in Roadside Drug Testing

Reference: Skopp G., Pötsch L., International Journal Legal Medicine, 1999, Volume 112:213-221.

Phencyclidine, Lysergic Acid Diethylamide, and Mescaline: Cerebral Artery Spasms and Hallucinogenic Activity

Reference: Altura BT, et al: Science, May 29,1981 May 29;212:1051-1052.

Possible Roles for Frequent Salivary Antiepileptic Drug Monitoring in the Management of Epilepsy

Reference: Herkes GK, Eadie MJ, Epilepsy Res., 1990, Volume 6, 146-154.

Rat Cocaethylene and Benzoylecgonine Concentrations in Plasma and Parotid Saliva after the Administration of Cocaethylene

Reference: Barbieri E.J., DiGregorio G.J., Ferko A.P., Ruch E.K., Journal of Analytical Toxicology, January/February 1994, Volume 18, 60-61.

Risks of Random Drug Testing

Reference: Caidin M: Aviation Safety, June 15, 1993; 6-8.

Saliva As A Diagnostic Fluid

Reference: Malamud D, Tabak L, Annals of the New York Academy of Sciences, 1993, Volume 694, 276-279.

Saliva Collection Technique for Cytologic, Microbiologic and Viral Evaluation in Pediatric HIV Infection

Reference: Flaitz CM, Hicks MJ, Carter AB, Rossmann SN, Demmler GJ, Simon CL, Cron SG, Shearer WT, Kline MW, Journal of Dentistry for Children, September - October 1998, 318-324.

Saliva: Emerging Specimen of Choice?

Reference: The Genesis Report - June 1991.

Salivary Anticonvulsant Levels in Children: A Comparison of Methods

Reference: Goldsmith R.F., Ouvrier R.A., Therapeutic Drug Monitoring, 1981, Volume 3, Number 2, 151-157.

Salivary Flow in Health and Disease

Reference: Sreebny L.M., DDS,MS,PhD Professor: Compend Contin Educ Dent, Suppl. Number 13, S461-S469.

Saliva Monitoring of Anticonvulsants

Reference: Reynolds F, Knott C: Journal of Clinical Chemistry Clin Biochem. 1989, Volume 27, Number 4, 226-227.

Saliva Secretion Rate in a Group of Drug Addicts (short communication)

Reference: Scheutz F, Scand. J. Dental Res., Volume 91, Number 16, 1983; 496-498.

Saliva Testing for Drugs of Abuse

Reference: Edward J. Cone, Addiction Research Center, National Institute on Drug Abuse.

Salivary Immunoglobulins: Normal Adult Values and Dissociation Between Serum and Salivary Levels

Reference: Claman HN, Merrill DA, Hartley TF: J. Allergy, September 1967, Volume 40, Number 3, 151-159.

Screening for Drugs of Abuse: (II): Cannabinoids, Lysergic Acid Diethylamide, Buprenorphine, Methadone, Barbiturates, Benzodiazepines and Other Drugs

Reference: Simpson D, Braithwaite RA, Jarvie DR, Stewart MJ, Walker S, Watson IW, Widdop B, Ann Clin Biochem, 1997, Volume 34, 460-510.

Selected Strategies for Improving Sensitivity and Reliability of Immunoassays

Reference: Larry J. Kirka, Clinical Chemistry, 1994, Volume 40, Number 3, 347-357.

Simultaneous Assay of Cocaine, Heroin, and Metabolites in Hair, Plasma, Saliva and Urine by Gas Chromatography/Mass Spectrometry

Reference: Wang W, Darwin W D, Cone EJ: Journal of Chromatography B, 1994, 660:279-290.

Simultaneous Determination of Carbamazepine, Phenytoin, Phenobarbital, Primidone and Their Principal Metabolites by High-Performance Liquid Chromatography with Photodiode-Array Detection

Reference: Liu H, Delgado M, Forman LJ, Eggers CM, Montoya JL: Journal of Chromatography, 1993, Volume 616:105-115.

Specificity of the Cannabinoid Metabolite and Phencyclidine EMIT d.a.u. Assays

Reference: Allen Jr., L.V., Stiles M.L., Journal of Analytical Toxicology, January/February 1988, Volume 12, 45-47.

Testing for Drugs of Abuse in Saliva and Sweat

Reference: Kidwell DA, Holland JC, Athanaselis S: Journal of Chromatography B. 713 (1998);111-135

The Application of Saliva in Laboratory Medicine - Report on the Workshop Conference

Also includes: Interpretation of Salivary Drug Concentrations, Saliva Monitoring of Anticonvulsants, and Value of Saliva Anticonvulsant Monitoring in Pregnancy and the Newborn

Reference: Haeckel R.: Journal Clin. Chem. Clin. Biochem., 1989, Volume 27:221-252.

The Distribution of Anti-Epileptic Drugs Between Serum, Saliva and Cerebrospinal Fluid

Reference: Blom G.F., Guellen P.J.M.: Antiepileptic Drug Monitoring, Pitman Medical Publishing Company, Ltd. - Kent, England.

The Effects of Adulterating Agents on FPIA Analysis of Urine for Drugs of Abuse

Reference: Schwarzhoff R, Cody JT, Journal of Analytical Toxicology, January/February 1993, Volume 17, 14-17.

The Effect of Dietary Energy and Protein Deficiency on Drug Metabolism

Reference: Hamberg O., Ovesen L., Dorfeldt A., Loft S., Sonne J., Eur J Clin Pharmacol, 1990, Volume 38, 567-570.

The Medical Review Officer

Reference: Macdonald DI: Journal of Psychoactive Drugs, 1990, Volume 22:439-434.

The Monitoring of Saliva Drug Levels: Psychiatric Applications

Reference: El-Guebaly N, Davidson WJ, Sures HA, Griffin W: Can. J. Psychiatry, February 1981, Volume 26, Number 1, 43-48.

The Place of Saliva in Antiepileptic Drug Monitoring

Reference: Knott C., Reynolds F., Therapeutic Drug Monitoring, Volume 6, Number 1, 1984, 35-41.

Therapeutic Drug Monitoring in Saliva

Reference: Danhof M., Breimer D.D., Clinical Pharmacokinetics, 1978, Volume 3, 39-57.

The Sodium Concentration of Parotid Saliva in "Hard" Drug Addicts

Reference: Willis J, Aylett P, The International Journal of the Addictions, 1973, Volume 8, Number 3, 569-576.

The Use of Saliva in Therapeutic Drug Monitoring

Reference: Mucklow J.C., Therapeutic Drug Monitoring, 1982, Volume 4, Number 3, 229-247.

The Value of Premedication in Diminishing Salivary Secretions

Reference: Kamel M, Tewfik O, Ibrahim S: Middle East J. Anesthesiology, June 1975, Volume 4, Number 5, 363-371.

Urine Testing for Drugs of Abuse

Reference: Hawks RL, Chiang CN, NIDA Research Monograph 73, 1986, 85-92.

Use of Saliva in Therapeutic Drug Monitoring

Reference: Horning M.G., Brown L., Nowlin J., Lertratanangkoon K., Kellaway P., Zion T.E.: Clinical Chemistry, 1977, Volume 23, No. 2, 157-164.

Value of Saliva Anticonvulsant Monitoring in Pregnancy and the Newborn

Reference: Knott C, Reynolds F: Journal Clinical Chemistry Clin Biochem, 1989, Volume 27, Number 4, 227-228.

 

AMPHETAMINES:

A Broad Spectrum Immunoassay Using Fluorescence Polarization for the Detection of Amphetamines in Urine.

Reference: Turner G.J., Colbert D.L., Chowdry B.Z.: Ann Clin Biochem 1991; Volume 28, Part 6, 588-594.

Detection of Amphetamine in Bloodstains, Semen, Seminal Stains, Saliva and Saliva Stains

Reference: Smith FP: Forensic Science, 1981, Volume 17, 225-228.

Evaluation of Six Commercial Amphetamine and Methamphetamine Immunoassays for Cross-Reactivity to Phenylpropanolamine and Ephedrine in Urine

Reference: D'Nicuola J., Jones R., Levine B., Smith M.L., Journal of Analytical Toxicology, July/August 1992, Volume 16, 211-213.

Kinetics, Salivary Excretion of Amphetamine Isomers, and Effect of Urinary pH

Reference: Suk Han Wan, Ph.D., Shaikh B. Matin, Ph.D., Daniel L. Azarnoff, M.D;

0009-9236/78/0523-0585 Ó May 1978 The C.V. Mosby Company, Volume 23, Number 5, 585-590.

Quantitative Determination of Enantiomeric Compounds - I-Simultaneous Measurement of the Optical Isomers of Amphetamine in Human Plasma and Saliva Using Chemical Ionization Mass Spectrometry

Reference: Matin SB, Wan SH, Knight JB, Biomed. Mass Spectrom, April 1977, Volume 4, Number 2:118-121.

Radioimmunoassay of Amphetamines in Rat Parotid Saliva

Reference: Digregorio GJ, Kniaz EK: Drug and Alcohol Dependence, 1975-76, Volume 1, 377-382.

Ranitidine Interference with the Monoclonal EMIT d.a.u. Amphetamine/Methamphetamine Immunoassay

Reference: Poklis A, Hall KV, Still J, Journal of Analytical Toxicology, March/April 1991, Volume 15, 101-103.

Using Amphetamine Isomer Ratios to Determine the Compliance of Amphetamine Abusers Prescribed Dexedrine

Reference: George S, Braithwaite RA, Journal of Analytical Toxicology, April 2000, Volume 24, 223-227.

 

BARBITURATES:

Analysis of Trace Amounts of Barbiturates in Saliva

Reference: Dilli S., Pillai D.: Journal of Chromatography, 1980, Volume 190:113-118.

Assay for Cyclo-, Seco-, and Pentobarbital by Multiple Ion Detection: Kinetics After a Single Dose

Reference: Steudel H, Steudel A, von Unruh GE: Journal Clin. Chem. Clin. Biochem., Volume 20, Number 4, 1982:267-269.

Comparison of Saliva Secretion Rate and Composition in the Rat Using a Pentobarbital or a Neuroleptanalgesic Type of Anaesthesia

Reference: Johansson I., Linder J., Bratt P., Caries Res 1989, Volume 23:75-77.

Correlation Between the Saliva and Free Serum Concentration of Phenobarbital in Epileptic Children

Reference: Tokugawa K., Ueda K., Fujito H., Kurokawa T.: European Journal of Pediatrics, 1986, Volume 145, 401-402.

Detection of Phenobarbital in Bloodstains, Semen, Seminal Stains, Saliva, Saliva Stains, Perspiration Stains, and Hair

Reference: Smith F.P., Pomposini D.A.: Journal of Forensic Sciences, July 1981, Volume 26, 582-586.

Estimation of Plasma Unbound Phenobarbital Concentration by Using Mixed Saliva

Reference: Nishihara K., Uchino K., Saitoh Y., Honda Y., Nakagawa F., Tamura Z.: Epilepsia, 1979, Volume 20, 37-45.

Identification and Differentiation of Barbiturates, Other Sedative-Hypnotics and Their Metabolites in Urine Integrated in a General Screening Procedure Using Computerized Gas Chromatography-Mass Spectrometry

Reference: Maurer H.H., Journal of Chromatography, 1990, Volume 530, 307-326.

Influence of Salivary pH on the Correlation Between Salivary and Plasma Levels of Phenobarbital in the Neonatal Period

Reference: Fabris C, Licata D, Tappi E, Cavo L, Voglino GF, Minerva Pediatr, 1989, Volume 41, Number 1, 45-46. (Italian)

Liquid Chromatographic Determination of Barbiturates using a Hollow-Fibre Membrane for Postcolumn pH Modifications

Reference: Haginaka J., Wakai J.: Journal of Chromatography, 1987, Volume 390:421-428.

Pharmacokinetics of Orally Administered Hexobarbital in Plasma and Saliva of Healthy Subjects

Reference: Van Der Graaff M., Vermeulen N.P.E., Heij P., Boeijinga J.K., Breimer D.D.: Biopharmaceutics & Drug Disposition, 1986, Volume 7, 265-272.

Phenobarbital Pharmacokinetics and Salivary and Serum Concentrations in Pregnancy

Reference: Luoma PV, Heikkinen JE, Ylöstalo PR, Therapeutic Drug Monitoring, 1982, Volume 4, Number 1, 65-68.

Phenytoin and Phenobarbital Concentrations in Saliva and Plasma Measured by Radioimmunoassay

Reference: Cook C.E., Amerson E., Poole W.K., Lesser P., O’Tuama L.: Clinical Pharmacology and Therapeutics, 1975, Volume 18, Number 6, 742-747.

Possible Roles for Frequent Salivary Antiepileptic Drug Monitoring in the Management of Epilepsy

Reference: Herkes G.K., Eadie M.J., Epilepsy Res., 1990, Volume 6, 146-154.

Prevention of Gastrointestinal Absorption of Phenobarbital by Activated Carbon Beads as an Oral Adsorbent

Reference: Honda Y, Nakano M, Nakano NI, Journal Pharmacbio-Dyn., 1990, Volume 13, 597-601.

Rapid Trace Analysis of Barbiturates in Blood and Saliva by High-Pressure Liquid Chromatography

Reference: Tjaden U.R., Kraak J.C., Huber J.F.K.: Journal of Chromatography, 1977, Volume 143:183-194.

Saliva Phenobarbital and Phenytoin Concentrations in Epileptic Adolescents

Reference: Friedman I.M., Litt I.F., Henson R., Holtzman D., Halverson D.: The Journal of Pediatrics, 1981, Volume 98, Number 4:645-647.

Salivary Excretion of Amobarbital in Man

Reference: Inaba T., Kalow W.: Clinical Pharmacology and Therapeutics, 1975, Volume 18, Number 5, 558-562.

 

BENZODIAZEPINES:

A Novel Method for Measuring Benzodiazepines in Saliva

Reference: Rosenblatt. J.E., Bridge T.P., Wyatt R.J.: Communications in Psychopharmacology, 1979, Volume 3, 49-53.

Determination of Some Benzodiazepines and Metabolites in Serum, Urine, and Saliva by High-Performance Liquid Chromatography

Reference: Tjaden U.R., Meeles M.T.H.A., Thys C.P., Van Der Kaay M.: Journal of Chromatography, 1980, Volume 181:227-241.

False-Positive Immunoassay Results for Urine Benzodiazepine in Patients Receiving Oxaprozin

Reference: Camara PD, Audette L, Velletri K, Breitenbecher P, Rosner M, Griffiths WC: Clinical Chemistry, Volume 41, Number 1, 1995:115-116.

Identification of Urinary Benzodiazepines and their Metabolites: Comparison of Automated HPLC and GC/MS after Immunoassay Screening of Clinical Specimens

Reference: Valentine JL, Middleton R, Sparks C: Journal of Analytical Toxicology, October 1996, Volume 20, 416-424.

Saliva Benzodiazepine Levels and Clinical Outcome in Detoxifying Alcoholic Patients

Reference: Bridge TP, Rosenblatt JE, Burbach RV, Wyatt RJ: Communications in Psychopharmacology, 1980, Volume 4, 367-381.

Serum Albumin Binding of Some Benzodiazepines: Practical Implications for the Relation Between Free Serum and Saliva Concentrations

Reference: t'Hart BJ, Pharmaceutisch Weekblad Scientific Edition, 1988, Volume 10, 287-288.

Solid-Phase Microextraction and GC-ECD of Benzophenones for Detection of Benzodiazepines in Urine

Reference: Guan F, Seno H, Ishii A, Watanabe K, Kumazawa T, Hattori H, Suzuki O: Journal of Analytical Toxicology, January/February 1999, Volume 23, 54-61.

The Determination of Salivary pH by Contact pH Meter in Individuals Receiving Psychotropic Therapy. Study of pH on the Tongue and at the Orifice of Wharton's and Stenon's ducts.

Reference: Gomez C, Gachon AM, Peri G, Dastugue B, Revue de Stomatologie, Paris, 1978, Volume 79, Number 6, 475-481.

The Stability of Benzodiazepines in Saliva

Reference: t'Hart BJ, Wilting J, deGier JJ, Meth and Find Exptl Clinical Pharmacology, 1988, Volume 10, Number 1, 21-26.

 

BETA BLOCKERS:

Acebutolol Saliva Excretion

Reference: Giudicelli JF, Freslon JL, Richer C: Brit. Journal of Clinical Pharmacology, 1979, Volume 8, 373-375.

Comparison of Plasma and Saliva Levels of Metoprolol and Oxprenolol

Reference: Dawes CP, Kendall MJ: British Journal of Clinical Pharmacology, 1978, Volume 5, 217-221.

Plasma Levels with b -Adrenoceptor Blockage with Acebutolol, Practolol and Propranolol in Man

Reference: Cuthbert MF, Collins RF, Br. Journal Clinical Pharmacology, 1975, Volume 2, 49-55.

Plasma Propranolol Levels in Adults (with Observations in Four Children)

Reference: Shand DG, Nuckolls EM, Oates JA, Clin Pharmac Therapy, 1970, Volume 11, Number 1, 112-120.

Plasma-Salivary Ratios of Acebutolol and Propranolol

Reference: Kaye C, Orton D, Taylor E, Brunell C: Brit. Journal of Clinical Pharmacology, September 1977, 724P.

The Use of Electron Impact and Positive Chemical Ionization Mass Spectrometry in the Screening of Beta Blockers and Their Metabolites in Human Urine

Reference: Leloux M.S., Maes R.A.A., Biomedical and Environmental Mass Spectrometry, 1990, Volume 19, 137-142.

 

CANNABINOIDS:

Blood Cannabinoids: I. Absorption of THC and Formation of 11-OH-THC and THCCOOH During and After Smoking Marijuana

Reference: Huestis M.A., Henningfield J.E., Cone E.J., Journal of Analytical Toxicology, September/October 1992, Volume 16, 276-282.

Blood Cannabinoids: II. Models for the Prediction of Time of Marijuana Exposure from Plasma Concentrations of D 9-Tetrahydrocannabinol (THC) and 11-nor-9-Carboxy-D 9-Tetrahydrocannabinol (THCCOOH)

Reference: Heustis M.A., Henningfield J.E., Cone E.J., Journal of Analytical Toxicology, September/October 1992, Volume 16, 283-290.

Cannabinoids in Blood and Urine After Passive Inhalation of Cannabis Smoke

Reference: Morland J, Bugge A, Skuterud B, Steen A, Holst Wethe G, Kjeldsen T: Journal of Forensic Science, 1985, Volume 30, 997-1002.

Cannabinoids: Influence on Neurotransmitter Uptake in Rat Brain Synaptosomes

Reference: Banerjee SP, Snyder SH, Mechoulam R, The Journal of Pharmacology and Experimental Therapeutics, 1975, Volume 194, Number 1, 74-81.

Clinical Effects and Plasma Levels of D 9-Tetrahydrocannabinol (D 9-THC) in Heavy and Light Users of Cannabis

Reference: Lindgren J, Ohlsson A, Agurell S, Hollister L, Gillespie H: Psychopharmacology 1981, Volume 74:208-212.

Comparison of the Effects of the Isomers of D 9-Tetrahydrocannabinol on the Longitudinal Strip of Guinea Pig Ileum

Reference: Roth SH, Proc. Can. Fed. Biol. Society,1976, Volume 19, Page 21.

Concentration-Effect Relationship of D 9-Tetrahydrocannabiol and Prediction of Psychotropic Effects after Smoking Marijuana

Reference: Harder S, Rietbrock S: International Journal of Clinical Pharmacology and Therapeutics, 1997, Volume 35, Number 4, 155-159.

Confirmation of Cannabis Use by the Analysis of D 9-Tetrahydrocannabinol Metabolites in Blood and Urine by Combined HPLC and RIA

Reference: Law B, Mason PA, Moffat AC, King LJ: Journal of Analytical Toxicology, January/February 1984, Volume 8:19-22.

Cross-Tolerance Between Inhaled Cannabis and Intraperitoneal Injections of D 9-THC

Reference: Fried PA: Pharmacology Biochemistry & Behavior, 1976, Volume 4:635-638.

Delta-8 and Delta-9 Tetrahydrocannabinol: Comparison in Man by Oral and Intravenous Administration

Reference: Hollister LE, Gillespie HK, Clinical Pharmacology and Therapeutics, 1973, Volume 14, Number 3, 353-357.

Detection of Recent Cannabis Use by Saliva D 9-THC Radioimmunoassay

Reference: Gross SJ, Worth TE, Nerder L, Zimmerman EG, Soares JR: Journal of Analytical Toxicology, January/February 1985, Volume 9:1-5.

Detection of D 9-THC in Saliva by Capillary GC/ECD After Marijuana Smoking

Reference: Maseda C, Hama K, Fukui Y, Matsubara K, Takahashi S, Akane A: Forensic Science International, 1986, Volume 32:259-266.

Determination of Cannabinoids in Water and Human Saliva by Solid-Phase Microextraction and Quadrupole Ion Trap Gas Chromatography/Mass Spectrometry

Reference: Hall B.J., Satterfield-Doerr M., Parikh A.R., Brodbelt J.S.: Analytical Chemistry, .May 1, 1998, Volume 70, Number 9:1788-1796.

Determination of D 9-Tetrahydrocannabinol in Human Blood and Saliva by High-Performance Liquid Chromatography with Amperometric Detection

Reference: Thompson L.K., Cone E.J.,: Journal of Chromatography, 1987, Volume 421:91-97;

Biomedical Applications, Elsevier Science Publishers, B.V., Amsterdam

Determination of Urinary Cannabinoid Metabolites Following Incidental Exposure to Marijuana Smoke

Reference: Ferslew KE, Manno JE, Manno BR: Research Communications in Substances of Abuse, 1983, Volume 4, Number 4:289-300.

Effect of Subject Expectancy on the THC Intoxication and Disposition From Smoked Hashish Cigarettes

Reference: Cami J, Guerra D, Ugena B, Segura J, De La Torre R: Pharmacology Biochemistry & Behavior, 1991, Volume 40:115-119.

Forensic Aspects of the Metabolism and Excretion of Cannabinoids Following Oral Ingestion of Cannabis Resin

Reference: Law B, Mason PA, Moffat AC, Gleadle RI, King LJ: J. Pharm. Pharmacol, 1984, Volume 36:289-294.

Formation of Tetrahydro-b -Carbolines in Human Saliva

Reference: Tsychiya H, Ohtani S, Yamada K, Tajima K, Sato M: Biochemical Pharmacology, 1995, Volume 50, Number 12:2109-2112.

Human Urinary Excretion Profile after Smoking & Oral Administration of [14C] D 1-Tetrahydrocannabinol

Reference: Johansson E, Gillespie HK, Halldin MM: Journal of Analytical Toxicology, May/June 1990, Volume 14:176-180.

Hypochlorite Adulteration of Urine Causing Decreased Concentration of D 9-THC-COOH by GC/MS

Reference: Baiker C., Serrano L., Lindner B., Journal of Analytical Toxicology, March/April 1994, Volume 18, 101-103.

Interpretation of Blood and Urine Cannabinoid Concentrations

Reference: McBay AJ, Journal of Forensic Sciences, 1988, Volume 33, Number 4, 875-883

Passive Inhalation of Cannabis Smoke

Reference: Law B, Mason PA, Moffat AC, King LJ, Marks V: J. Pharm. Pharmacol, 1984, Volume 36:578-581

Passive Smoking of Cannabis

Reference: Ramadas D, Moyes CD: New Zealand Medical Journal, 109(1030):366, 9/27/96.

Plasma Delta-9-Tetrahydrocannabinol Concentrations and Clinical Effects After Oral and Intravenous Administration and Smoking

Reference: Ohlsson A, Lindgren JE, Wahlen A, Agurell S, Hollister LE, Gillespie HK: Clinical Pharmacol. Ther. September 1980, Volume 28, Number 3:409-416.

Reinforcing and Subjective Effects of Oral D 9- THC and Smoked Marijuana in Humans

Reference: Chait L.D., Zacny J.P., Psychopharmacology, 1992, Volume 107, 255-262.

Relationships Between Several Pharmacokinetic Parameters and Psychometric Indices of Subjective Effects of D -9-Tetrahydrocannabinol in Man

Reference: Miller LL, Cocchetto DM, Perez-Reyes M: European Journal of Clinical Pharmacology, 1983, Volume 25:633-637.

Salivary THC Following Cannabis Smoking Correlates with Subjective Intoxication and Heart Rate

Reference: Menkes DB, Howard RC, Spears GFS, Cairns ER, Psychopharmacology, 1991, Volume 103, 277-279.

Screening for Cannabinoids in Blood Using EMIT: Concentrations of D 9-Tetrahydrocannbinol in Relation to Emit Results

Reference: Gjerde H, Forensic Science International, 1991, Volume 50, 121-124.

Simultaneous Quantitation of Delta-9-Tetrahydrocannabinol (THC) and 11-Nor-9-Carboxy-Delta-9-Tetrahydrocannabinol (THC-COOH) in Serum by GC/MS Using Deuterated Internal Standards and Its Application to a Smoking Study and Forensic Cases

Reference: Moeller MR, Doerr G, Warth S: Journal of Forensic Science, 1992, Volume 37 Number 4, 967-983.

Stability of 11-Nor D 9-Tetrahydrocannabinol in Negative Human Urine in High-Density Polethylene (Nalgene®)

Reference: Giardino NJ: Journal of Analytical Toxicology, July/August 1996, Volume 20, 275-276.

The Constituents of Cannabis and the Disposition and Metabolism of Cannabinoids

Reference: Hawks RL: National Institute on Drug Abuse, Research Monograph No 42, 125-137.

The Effects of D 9-Tetrahydrocannabinol on Action Potentials in the Mollusc Aplysia

Reference: Acosta-Urquidi J, Chase R,

The Pyrolysis of Cannabinoids

Reference: Tjeerdema RS, Reviews of Environmental Contamination and Toxicology, 1987, Volume 99, 61-81.

Urinary Excretion Half-Life of D 1-Tetrahydrocannabinol-7-oic Acid in Heavy Marijuana Users after Smoking

Reference: Johansson E, Halldin MM: Journal of Analytical Toxicology, Volume 13, July/August 1989:218-223.

Urinary Excretion of 11-nor-9-Carboxy-D 9 - Tetrahydrocannabinol and Cannabinoids in Frequent and Infrequent Drug Users

Reference: Smith-Kielland A., Skuterud B., and Morland J: Journal of Analytical Toxicology, September 1999, Volume 23, 323-332.

Urinary Excretion Profiles of 11-Nor-9-Carboxy-D 9-Tetrahydrocannabinol: A -D 9-THCCOOH to Creatinine Ratio Study

Reference: Fraser A.D., Worth, D: Journal of Analytical Toxicology, October 1999, Volume 23, 531-534.

 

CHLORDIAZEPOXIDE:

Chlordiazepoxide Concentrations in Saliva and Plasma Measured by Radioimmunoassay

Reference: Lucek R., Dixon R.: Research Communications in Chemical Pathology and Pharmacology, February 1980, Volume 27, Number 2, 397-400.

 

COCAINE:

Cocaine and Metabolite Excretion in Saliva under Stimulated and Nonstimulated Conditions

Reference: Kato K., Hillsgrove M., Weinhold L., Gorelick D.A., Darwin W.D., Cone E.J.: Journal of Analytical Toxicology, October 1993, Volume 17, 338-341.

Cocaine Contamination of United States Paper Currency

Reference: Oyler J, Darwin WD, Cone EJ: Journal of Analytical Toxicology, July/August 1996, Volume 20, 213-216.

Cocaine Disposition in Saliva Following Intravenous, Intranasal, and Smoked Administration

Reference: Cone E.J., Oyler J., Darwin W.D., Journal of Analytical Toxicology, October 1997, Volume 21, 465-475.

Cocaine in Hair, Saliva, Skin Swabs, and Urine of Cocaine Users' Children

Reference: Smith FP, Kidwell DA, Forensic Science International, 1996, Volume 83, 179-189.

Comparison of Heroin and Cocaine Concentrations in Saliva with Concentrations in Blood and Plasma

Reference: Jenkins A.J., Oyler J.M., Cone E.J.: Journal of Analytical Toxicology, October 1995, Volume 19, 359-374.

Confirmation of Cocaine in Human Saliva After Intravenous Use

Reference: Thompson L.K., Yousefnejad D., Kumor K., Sherer M., Cone E.J., Journal of Analytical Toxicology, January/February 1987, Volume 11, 56-58.

Correlation of Buccal Mucosal Transudate Collected with a Buccal Swab and Urine Levels of Cocaine

Reference: Leonard J, Doot M, Martin C, Airth-Kindree W, Journal of Addictive Diseases, 1994, Volume 13, Number 1, 27-32.

Correlation of Saliva Cocaine Levels with Plasma Levels and with Pharmacologic Effects after Intravenous Cocaine Administration in Human Subjects

Reference: Cone EJ, Kumor K, Thompson LK, Sherer M, Journal of Analytical Toxicology, July/August 1988, Volume 12, 200-206.

External Contamination of Hair by Cocaine: An Issue in Forensic Interpretation

Reference: Blank D.L., Kidwell D.A., Forensic Science International, 1993, Volume 63, 145-156.

Immunoassay for Detection of Cocaine/Metabolites in Oral Fluids

Reference: Niedbala RS, Kardos K, Fries T, Cannon A, Davis A, Journal of Analytical Toxicology, January/February 2001, Volume 25, 62-68.

Passive Freebase Cocaine ('Crack') Inhalation by Infants and Toddlers

Reference: Bateman DA, Heagarty MC: American Journal of Diseases of Children, January 1989, Volume 143, 25-27.

Passive Inhalation of Cocaine

Reference: Baselt RC, Yoshikawa DM, Chang JY: Clinical Chemistry, 1991, Volume 37, Number 12, 1991:2160-2161.

Passive Inhalation of Cocaine

Reference: Cone EJ, Yousefnejad D, Hillsgrove MJ, Holicky B, Darwin WD: Journal of Analytical Toxicology, October 1995, Volume 19, 399-411.

Prolonged Detection Period for Cocaine and Metabolite

Reference: J Clin Psychiatry, August 1990, Volume 51, Number 8, 347.

Prolonged Occurrence of Cocaine in Human Saliva and Urine After Chronic Use

Reference: Cone E.J., Weddington Jr. W.W., Journal of Analytical Toxicology, March/April 1989, Volume 13, 65-68.

Stability of Cocaine in Saliva

Reference: Cone EJ, Menchen SL: Clinical Chemistry, 1988, Volume 34, Number 7, 1508.

Unsuspected Cocaine Exposure in Young Children

Reference: Kharasch SJ, Glotzer D, Vinci R, Weitzman M, Sargent J: American Journal of Diseases of Children, February 1991, Volume 145, 204-206.

 

COTININE:

Does Pooling Saliva for Cotinine Testing Save Money Without Losing Information?

Reference: Bell R.M., Ellickson P.L.: Journal of Behavioral Medicine, 1989, Volume 12, Number 5, 503-507.

Highly Sensitive Immuno-Assays for the Determination of Cotinine in Serum and Saliva

Reference: Benkirane S., Nicolas A., Galteau M., Siest G.: Eur .J. Clin. Chem. Clin. Biochem/ 1991, Volume 29, Number 6, 405-410.

Nicotine Concentrations in Urine and Saliva of Smokers and Non-Smokers

Reference: Feyerabend C., Higenbottam T., Russell M.: British Medical Journal, April 3, 1982, Volume 284, 1002-1004.

Passive Exposure to Tobacco Smoke: Saliva Cotinine Concentrations in a Representative Population Sample of Non-Smoking Schoolchildren

Reference: Jarvis M.J., Russell M., Feyerabend C., Eiser J.R., Morgan M., Gammage P., Gray E.M.: British Medical Journal, October 5, 1985, Volume 291, 927-929.

Properties of Saliva Cotinine in Young Adult Light Smokers

Reference: Carey K.B. Ph.D., Abrams D.B. Ph.D.: American Journal of Public Health, 0090-0036/88, July 1988, Volume 78, Number 7, 842-843.

Relative Sensitivity and Specificity of Salivary and Serum Cotinine in Identifying Tobacco-Smoking Status of Self-Reported Nonsmokers and Smokers of Tobacco and/or Marijuana

Reference: Van Vunakis H., Ph.D., Tashkin D.P., M.D., Rigas B., M.D., Simmons M., Gjika H.B., Clark V.A., Ph.D.: Archives of Environmental Health, January/February 1989, Volume 44, Number 1, 53-58.

Saliva Cotinine as a Measure of Smoking Status in Field Settings

Reference: Abrams D.B., Ph.D., Follick M.J., Ph.D, Biener L., Ph.D.Carey K.B., Ph.D., Hitti J., BS: American Journal of Public Health 0090-0036/87 July 1987, Volume 77, Number 7, 846-848..

Serum and Saliva Concentrations of Cotinine in Smokers and Passive Smokers

Reference: Jarczyk L., Scherer G., Adlkofer F.: J. Clin. Chem. Clin. Biochem.,1989, Volume 27, Number 4, 230-231.

Situational Factors and Patterns Associated with Smokeless Tobacco Use

Reference: Hatsukami D.K., Anton D., Callies A., Keenan R.: Journal of Behavioral Medicine,

1991, Volume 14, Number 4, 383-396.

Some Properties of Saliva Cotinine Measurements in Indicating Exposure to Tobacco Smoking

Reference: Di Giusto E., BSc, Eckhard I, Ph.D.: American Journal of Public Health, October 1986, Volume 76, Number 10, 1245-1246.

 

DIAZEPAM:

A Rapid Capillary Gas Chromatographic Method for the Determination of Diazepam in Human Plasma and Saliva

Reference: Klebovich I., Kapas M., Vereczkey L.: Acta Pharmaceutica Hungarica, 1982, Volume 52, 246-252.

Clinical Pharmacokinetics of Diazepam

Reference: Mandelli M., Tognoni G., Garattini S., Clinical Pharmacokinetcs, 1978, Volume 3, 72-91.

Comparison of Plasma and Saliva Levels of Diazepam

Reference: deGier J.J., ‘t Hart B.J., Wilderink P.F., Nelemans F.A.: Br. J. Clin. Pharmac., 1980, Volume 10, 151-155.

Complications in Correlation Studies Between Serum, Free Serum, and Saliva Concentrations of Nitrazepam

Reference: t'Hart BJ, Wilting J, deGier JJ, Meth and Find Exptl Clinical Pharmacology, 1987; Volume 9, Number 2, 127-131.

Diazepam Concentrations in Parotid Saliva, Mixed Saliva, and Plasma

Reference: DiGregorio G.J., Piraino A.J., Ruch E.: Clin. Pharmacol. Ther., December 1978, Volume 24, Number 6, 720-725.

Diazepam and n-Desmethyldiazepam Concentrations in Saliva, Plasma and CSF

Reference: Hallstrom C., Lader M.H., Curry S.H.: Br. J. Clin. Pharmac., 1980,Volume 9, 333-339.

Diazepam and n-Desmethyldiazepam in Saliva of Hospital Inpatients

Reference: Giles H.G., Miller R., Macleod S.M., Seller E.M.: The Journal of Clinical Pharmacology,

February/March 1980, Volume 20, 71-76.

Diazepam: Determination in Micro Samples of Blood, Plasma, and Saliva by Radioimmunoassay

Reference: Dixon R., Crews T., Journal of Analytical Toxicology, September/October 1978, Volume 2, 210-213.

Disposition of Intravenous Diazepam in Young Men and Women

Reference: Giles HG, Sellers EM, Naranjo CA, Frecker RC, Greenblatt DJ: Eur J Clin Pharmacol, 1981, Volume 20, 207-213

Effect of Diazepam on Human Salivary Secretion

Reference: Steiner JE, Birnbaum D, Karmeli F, Cohen S: Digestion 3: 1970, 262-268.

Pharmacokinetics of Nitrazepam in Saliva and Serum after a Single Dose

Reference: Kangas L., Allonen H., Lammintausta R., Salomen M., Pekkarinen A.: Acta Pharmacol. Et Toxicology, Volume 45, 1979, 20-24.

Pharmacokinetic Profile of Diazepam in Man Following Single Intravenous and Oral and Chronic Oral Administrations

Reference: Kaplan SA, Jack ML, Alexander K, Weinfeld RE, Journal of Pharamceutical Sciences, 1973, Volume 62, Number 11, 1789-1796.

Psychomotor Performance and Real Driving Performance of Outpatients Receiving Diazepam

References: deGier J.J., ‘t Hart B.J., Nelemans F.A., Bergman H.: Psychopharmacology, 1981, Volume 73, 340-344.

Saliva and Plasma Concentration of Diazepam after a Single Oral Dose

Reference: Giles H.G., Zilm D.H., Frecker R.C., Macleod S.M., Sellers E.M.: British Journal Clinical Pharmac., 1977, Volume 4, 711-712.

Sensitive Gas Chromatographic Method for Determining Nitrazepam in Serum and Saliva

Reference: 't Hart BJ, Wilting J: Journal of Chromatography, 1988, Volume 424, 403-409.

 

ETHANOL:

False-Positive EMIT®-st™ Ethanol Screen with Post-Mortem Infant Plasma

Reference: Badcock NR, O'Reilly DA: Clinical Chemistry, 1992, Volume 38, Number 3, 434.

False-Positive Ethanol in Clinical and Postmortem Sera by Enzymatic Assay: Elimination of Interference by Measuring Alcohol in Protein-Free Ultrafiltrate

Reference: Thompson WC, Malhotra D, Schammel DP, Blackwell W, Ward ME, Dasgupta A: Clinical Chemistry, 1994, Volume 40, Number 8, 1594-1595.

False-Positive Ethanol Results by EMIT®

Reference: Thede-Reynolds K, Johnson GF: Clinical Chemistry, 1993, Volume 39, Number 6, 1143.

 

FENTANYL:

An Analysis of the Duration of Fentanyl and Its Metabolites in Urine and Saliva

Reference: Silverstein JH, Rieders MF, McMullin M, Schulman S, Zahl K: Anesthesia & Analgesia, 1993, Volume 76, Number 3, 618-621.

 

HEROIN:

Detection of O6-Monoacetylmorphine in Urine Samples by GC/MS as Evidence for Heroin Use

Fehn J, Megges G: Journal of Analytical Toxicology, May/June 1985, Volume 9, 134-138.

Gas Chromatography/Electron Impact Mass Fragmentometric Determination of Urinary 6-Acetylmorphine, a Metabolite of Heroin

Reference: Paul BD, Mitchell JM, Mell, Jr. LD: Journal of Analytical Toxicology, January/February 1989, Volume 13, 2-7.

Validity of Screening Methods for Drugs of Abuse in Biological Fluids - II. Heroin in Plasma and Saliva

Reference: Gorodetzky CW, Kullberg MP: Clinical Pharmacology and Therapeutics, 1974, Volume 15, 579-587.

 

LSD:

Confirmation of LSD Intoxication by Analysis of Serum and Urine

Reference: McCarron MM, Walberg CB, Baselt RC: Journal of Analytical Toxicology, May/June 1990, Volume 14, 165-167.

 

MARIJUANA:

A Cumulative Dosing Procedure for Administering Marijuana Smoke to Humans

Reference: Chait LD, Corwin RL, Johanson CE: Pharmacology Biochemistry & Behavior, 1988, Volume 29, 553-557.

Behavioral Pharmacokinetics of Marijuana

Reference: Barnett G, Licko V, Thompson T: Psychopharmacology, 1985, Volume 85, 51-56.

Characterization of the Absorption Phase of Marijuana Smoking

Reference: Huestis MA, Sampson AH, Holicky BJ, Henningfield JE, Cone EJ: Clin. Pharmacol. Ther., July 1992, Volume 52, Number 1, 31-41.

Comparison Effects of Marijuana Cigarettes of Three Different Potencies

Reference: Perez-Reyes M, Di Guiseppi S, Davis KH, Schindler VH, Cook CE: Clinical Pharmacology and Therapeutics, May 1982, Volume 31, Number 5, 617-624.

Detection Times of Marijuana Metabolites in Urine by Immunoassay and GC-MS

Reference: Huetis MA, Mitchell JM, Cone EJ: Journal of Analytical Toxicology, October 1995, Volume 19, 443-449.

Discriminative Stimulus and Subjective Effects of Smoked Marijuana in Humans

Reference: Chait LD, Evans SM, Grant KA, Kamien JB, Johanson CE, Schuster CR: Psychopharmacology 1988, Volume 94, 206-212.

Drug Testing in the Workplace: Could a Positive Test for One of the Mandated Drugs be for Reasons Other than Illicit Use of the Drug?

Reference: Elsohly MA, Jones AB: Journal of Analytical Toxicology, October 1995, Volume 19, 450-458.

Effects of Tetrahydrocannabinol Content on Marijuana Smoking Behavior, Subjective Reports and Performance

Reference: Heishman SJ, Stitzer ML, Yingling JE: Pharmacology Biochemistry & Behavior, 1988, Volume 34, 173-179.

Effects of Varying Marijuana Smoking Profile on Deposition of Tar and Absorption of CO and D 9-THC

Reference: Tashkin DP, Gliederer F, Rose J, Chang P, Hui KK, Yu JL, Wu TC: Pharmacology Biochemistry & Behavior, 1991, Volume 40, 651-656.

Embalming Fluid-Soaked Marijuana: New High or New Guise for PCP?

Reference: Holland JA, Nelson L, Ravikumar PR, Elwood WN: Journal of Psychoactive Drugs, April - June 1998, Volume 30, Number 2, 215-219.

Kinetic Study of Smoking Marijuana

Reference: Barnett G, Chiang CN, Perez-Reyes M, Owens SM: Journal of Pharmacokinetics and Biopharmaceutics, 1982, Volume 10, Number 5, 495-506.

Marijuana Carry-Over Effects on Aircraft Pilot Performance.

Reference: Leirer VO, Yesavage JA, Morrow DG: Aviation, Space and Environmental Medicine, March 1991, Volume 62, Number 3, 221-227.

Marijuana Effect and Delta-9-Tetrahydrocannabinol Plasma Level

Reference: Chiang CN, Barnett G: Clinical Pharmacol. Ther., 1984, Volume 36, Number 2, 234-238.

Marijuana Effects and Urinalysis After Passive Inhalation and Oral Ingestion

Reference: Cone EJ: National Institute of Drug Abuse, Research Monograph, 1990, Volume 99, 88-96.

Marijuana Smoking: Effect of Varying D 9-Tetrahydrocannabinol Content and Number of Puffs

Reference: Azorlosa JL, Heishman SJ, Stitzer ML, Mahaffey JM: The Journal of Pharmacology and Experimental Therapeutics, April 1992, Volume 261, Number 1, 114-122.

Marijuana Smoking: Factors that Influence the Bioavailability of Tetrahydrocannabinol

Reference: Perez-Reyes M: National Institute of Drug Abuse, Research Monograph, 1990, Volume 99, 42-62.

Passive Inhalation of Marijuana Smoke and Urinary Excretion of Cannabinoids

Reference: Perez-Reyes M, Di Guiseppi S, Mason AP, Davis KH: Clin. Pharmacol. Ther., 1983, Volume 34, Number 1, 36-41.

Passive Inhalation of Marijuana Smoke: Urinalysis and Room Air Levels of Delta-9-Tetrahydrocannabinol

Reference: Cone E.J., Johnson R.E., Darwin W.D., Yousefnejad D., Mell L.D., Paul B.D., Mitchell J., Journal of Analytical Toxicology, May/June 1987, Volume 11, 89-96.

Subjective and Behavioral Effects of Marijuana the Morning After Smoking

Reference: Chait L.D., Psychopharmacology, 1990, Volume 100, 328-333.

The Clinical Pharmacology and Dynamics of Marijuana Cigarette Smoking

Reference: Perez-Reyez M, Owens M, Di Guiseppi S: Journal Clin. Pharmacol, 1981, Volume 21, 201S-207S.

The Pharmacologic Effects of Daily Marijuana Smoking in Humans

Reference: Perez-Reyes M, White WR, McDonald SA, Hicks RE, Jeffcoat AR, Cook CE: Pharmacology Biochemistry & Behavior, 1991, Volume 40, 691-694.

 

METHADONE:

Analysis of Methadone and Metabolites in Biological Fluids with Gas Chromatography-Mass Spectrometry

Reference: Kang G.I., Abbott F.S.: Journal of Chromatography, 1982, Volume 231, 311-319.

Effect of Urinary pH on the Disposition of Methadone in Man

Reference: Nilsson MI, Widerlov E, Meresaar U, Anggard E: Eur Journal Clin Pharmacol, 1982, Volume 22, 337-342.

Methadone in Saliva

Reference: Clinical Chemistry, 1991, Volume 37, Number 71297-1298.

Therapeutic Drug Monitoring for Methadone: Scanning the Horizon

Reference: Wolff K, Strang J: European Addiction Research, 1999, Volume 5, 36-42.

The Secretion of Methadone and Its Major Metabolite in the Gastric Juice of Humans - Comparison with Blood and Salivary Concentrations

Reference: Lynn RK, Olsen GD, Leger RM, Gordon WP, Smith RG, Gerber N: Drug Metabolism and Disposition, 1975, Volume 4, Number 5, 504-509.

 

METHAMPHETAMINES:

Analysis of Methamphetamine in Hair, Nail, Sweat and Saliva by Mass Fragmentography

Reference: Suzuki S, Inoue T, Hori H, Inayama S, Journal of Analytical Toxicology, May/June 1989, Volume 13, 176-178.

Detection of a GC/MS Artifact Peak as Methamphetamine

Reference: Hornbeck C.L., Carrig J.E., Czarny R.J., Journal of Analytical Toxicology, September 1993, Volume 17, 257-263.

Resolution of Methamphetamine Stereoisomers in Urine Drug Testing: Urinary Excretion of R(-)-Methamphetamine Following Use of Nasal Inhalers

Reference: Fitzgerald R.L., Ramos, Jr. J.M., Bogema S.C., Poklis A., Journal of Analytical Toxicology, September/October 1988, 25, Volume 12, 255-259

Saliva and Plasma Methamphetamine Concentrations

Reference: Forensic Drug Abuse Advisor, November/December 2000, Volume 12, Number 10, 76.

 

METHAQUALONE:

Determination of Methaqualone and Its Major Metabolite in Plasma and Saliva After Single Oral Doses

Reference: Peat M.A., Chem C., Finkle B.S.: Journal of Analytical Toxicology, May/June 1980, Volume 4, 114-118.

 

MORPHINE:

Absolute Bioavailability of Hydromorphone After Peroral and Rectal Administration in Humans: Saliva/Plasma Ratio and Clinical Effects

Reference: Ritschel WA, Parab PV, Denson DD, Coyle DE, Gregg RV: Journal of Clin Pharmacol., 1987, Volume 27, 647-653.

Bioavailability of Sublingual Buprenorphine

Reference: Mendelson J, Upton RA, Everhart T, Jacob III P, Jones RT: Journal of Clin Pharmacol., 1997, Volume 37, 31-37.

Concentrations of Morphine and Codeine in Serum and Urine after Ingestion of Poppy Seeds

Reference: Hayes LW, Krasselt WG, Mueggler PA: Clinical Chemistry, 1987, Volume 33, Number 6, 806-808.

Excretion of Morphine in Urine Following the Ingestion of Poppy Seeds

Reference: Struempler RE, Military Medicine, September 1988, Volume 153, Volume 9, 468-470.

Gas Chromatographic/Mass Spectrometric Analysis of Morphine and Codeine in Human Urine of Poppy Seed Eaters

Reference: ElSohly HN, Stanford DF, Jones AB, ElSohly MA, Snyder H, Pedersen C: Journal of Forensic Science, 1988, Volume 33, 247-256.

Microbial Degradation of the Morphine Alkaloids: Identification of Morphinone as an Intermediate in the Metabolism of Morphine by Pseudomonas Putida M10

Reference: Bruce NC, Wilmot CJ, Jordan KN, Trebilcock AE, Gray Stephens LD, Lowe CR, Archives of Microbiology, 1990, Volume 154, 465-470.

Morphine and Codeine in Biological Fluids: Approaches to Source Differentiation

Reference: ElSohly MA, Jones AB: Forensic Science Review, Volume 1, Number 1, June 1989, 14-22.

Morphine Intake from Poppy Seed Food

Reference: Bjerver K, Jonsson J, Nilsson A, Schuberth J, Schuberth J: Journal of Pharm. Pharmacol. May 6, 1982, Volume 34, 798-801.

Morphine Levels in Urine Subsequent to Poppy Seed Consumption

Reference: Fritschi G, Prescott Jr. WR: Forensic Science International, 1985, Volume 27, 111-117.

Plasma Concentrations of Morphine, Morphine-3-Glucuronide, and Morphine-6-Glucuronide After Intravenous and Oral Administration to Healthy Volunteers: Relationship to Nonanalgesic Actions

Reference: Westerling D, Persson C, Hoglund P: Therapeutic Drug Monitoring, 1995, Volume 17, 287-301.

Roles of Divalent Metal Ions in Oxidations Catalyzed by Recombinant Cytochrome P450 3A4 and Replacement of NADPH - Cytochrome P450 Reductase with Other Flavoproteins, Ferredoxin and Oxygen Surrogates

Reference: Yamazaki H, Ueng Y, Shimada T, Guengerich FP, Biochemistry, 1995, Volume 34, Number 26, 8380-8389.

Stability-Indicating Spectrophotometric Determination of Morphine in Injectable Solutions Containing Bisulfite

Reference: Hundley HK, Castillo GD, Journal of the AOAC, 1974, Volume 57, Number 3, 738-740.

Testing Human Hair for Drugs of Abuse. I. Individual Dose and Time Profiles of Morphine and Codeine in Plasma, Saliva, Urine, and Beard Compared to Drug-Induced Effects on Pupils and Behavior

Reference: Cone EJ, Journal of Analytical Toxicology, January/February 1990, Volume 14, 1-7.

Transformations of Morphine Alkaloids by Pseudomonas Putida M10

Reference: Long MT, Hailes AM, Kirby GW, Bruce NC, Applied and Environmental Microbiology, October 1995, Volume 61, Number 10, 3645-3649.

 

OPIATES:

An Assessment of the Routes of Incorporation of Opiates into Beard Hair After a Single Oral Dose of Codeine.

Reference: Callaghan RR, Wilson JF, Cartwright: Therapeutic Drug Monitoring, 1996, Volume 18, 724-728.

Bioavailability of Tramadol After I.M. Injection in Comparison to I.V. Infusion

Reference: Lintz W, Beier H, Gerloff J, International Journal of Clinical Pharmacology and Therapeutics, 1999, Volume 37, Number 4, 175-183.

Codeine Testing in Sweat and Saliva with the Drugwipe

Reference: Kintz P, Cirimele V, Ludes B, Int Journal Legal Medicine, 1998, Volume 111, 82-84.

Correlation of Saliva Codeine Concentrations with Plasma Concentrations after Oral Codeine Administration

Reference: O'Neal C.L., Crouch D.J., Rollins D.E., Fatah A., Cheever M.L.: Journal of Analytical Toxicology, October 1999, Volume 23, 452-459.

Poppy Seed Ingestion and Opiates Urinalysis: A Closer Look

Reference: ElSohly H.N., ElSohly M.A., Stanford D.F., Journal of Analytical Toxicology, September/October 1990, Volume 14, 308-310.

Poppy Seed Ingestion as a Contributing Factor to Opiate-Positive Urinalysis Results: The Pacific Perspective

Reference: Selavka CM: Journal of Forensic Sciences, May 1991, Volume 36, Number 3, 685-696.

Presence of Rifampicin in Urine Causes Cross-Reactivity with Opiates using the KIMS Method

Reference: Trevilla PH, Jimenez EO, Tena T: Journal of Analytical Toxicology, May/June 1995, Volume 19, 200.

Spin Immunoassay of Opiate Narcotics in Urine and Saliva

Reference: Leute R, Ullman EF, Goldstein A: The Journal of the American Medical Association, September 11, 1972, Volume 221, Number 11, 1231-1234.

 

PHENCYCLIDINE (PCP):

Application of a Radioimmunoassay Screening Test for Detection and Management of Phencyclidine Intoxication

Reference: Kaul B, Davidow B: Journal Clinical Pharmacology, 1980, Volume 20, (8-9), 500-505.

Detection and Quantitation of Phencyclidine in Rat Parotid Saliva and Plasma

Reference: Digregorio GJ, Ruch E, Piraino AJ, Drug and Alcohol Dependence, 1981, Volume 8, 169-173.

Detection of Phencyclidine Usage by Radioimmunoassay of Saliva

Reference: McCarron M.M., Walberg C.B., Soares J.R., Gross S.J., Baselt R.C.: Journal of Analytical Toxicology, September/October 1984, Volume 8, 197-201..

Disposition of Phencyclidine After Intramuscular Administration

Reference: Chari-Bitron A., Edery H., Chen R., Motola L., Toxicology in the Use, Misuse and Abuse of Food, Drugs, and Chemicals, Arch. Toxicol., 1983, Supplement 6, 132-136.

Evaluation of Hair Root Analysis for Acute Phencyclidine Poisoning and Behavior of Phencyclidine Metabolites in Rat Hair Root.

Reference: Sakamoto T, Endo M, Nagasaki A, Nakamura A, Watanabe S, Tanaka A, Nakahara Y, Pharmazie, 1998, Volume 53, Number 5, 310-314.

Measurement of Phencyclidine in Saliva

Reference: Bailey DN, Guba JJ: Journal of Analytical Toxicology, Volume 4, November/December 1980, Volume 4, 311-313.

Occupational Intoxication and Long-Term Persistence of Phencyclidine (PCP) in Law Enforcement Personnel

Reference: Pitts FN, Allen RE, Aniline O, Yago LS: Clinical Toxicology, 1981, Volume 18, Number 9, 1015-1020.

Pharmacokinetic Bases for the Treatment of Phencyclidine (PCP) Intoxication

Reference: Done A, Aronow R, Miceli J, Cohen S: Veterinary and Human Toxicology, 1979, Supplement 21, 104-107.

Phencyclidine and Phenylcyclohexene Disposition After Smoking Phencyclidine

Reference: Cook CE, Brine DR, Quin GD, Perez-Reyes M, DiGuiseppi SR: Clinical Pharmacology and Therapeutics, 1982, Volume 31, Number 5, 635-641.

Phencyclidine Disposition after Intravenous and Oral Doses

Reference: Cook C.E., Ph.D., Brine D.R., B.S., Jeffcoat A.R., Ph.D., Hill J.M., M.S.,

Wall M.E., Ph.D., Perez-Reyes M., M.D., Di Guiseppi S.R., B.S.,: 0009-9236/82/050625+10

Ó 1982 The C.V. Mosby Company.

Phencyclidine Disposition in Humans after Small Doses of Radiolabeled Drug

Reference: Cook CE, Perez-Reyes M, Jeffcoat AR, Brine DR: Federation Proceedings, June 1983, Volume 42, Number 9, 2566-2569.

Phencyclidine Intoxication: A Literature Review

Reference: Sioris LJ, Krenzelok EP: American Journal of Hospital Pharmacy, November 1978, Volume 35, 1362-1367.

Phencyclidine Intoxication: Assessment of Possible Antidotes

Reference: Castellani S., Giannini A.J., Boeringa J.A., Adams P.M., Journal Toxicology: Clinical Toxicology, 1982, Volume 19, Number 3, 313-319.

Stability of Phencyclidine in Stored Blood Samples

Reference: Grieshaber A, Costantino A, Lappas N: Journal of Analytical Toxicology, October 1998, Volume 22, 515-519.

Urine pH and Phencyclidine Excretion

Reference: Perez-Reyes M, DiGuiseppi S, Brine DR, Smith H, Cook CE: Clinical Pharmacology Ther., November 1982, Volume 32, Number 5, 635-641.

 

INTERFERENT:

High Concentration of Ciprofloxacin in Urine Invalidates EMIT Results

Reference: Lora-Tamayo C, Tena T, Rodriguez A: Journal of Analytical Toxicology, September 1996, Volume 20.

High Concentration of Metronidazole in Urine Invalidates EMIT Results

Reference: Tamayo CL, Tena T: Journal of Analytical Toxicology, May/June 1991, Volume 15, 159.

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